br Funding br The author s disclosed
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was partly supported by a Grant-in-Aid for Niigata University of Health and Welfare, as well as the M.D. Anderson Cancer Center Support Grant CA 016672.
Declaration of Competing Interest
The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
The authors are grateful to the study participants and physical therapy students for their help in the collection of muscle strength and balance function data. This study was partly supported by a grant-in-aid for Niigata University of Health and Welfare, as well as an MD Anderson Cancer Center support grant (CA 016672).
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Journal of Coloproctology
Assessment of the non-surgical treatment of patients with rectal cancer who underwent neoadjuvant treatment with chemotherapy and radiotherapy at the oncology department
Meyline Andrade Lima a, Eduardo Dias de Moraes b, Elisa Yumi Saito c, Daniela Galvao Barros d, Pamela Souza Almeida Malta e,
Isabela Maria Alves de Almeida Oliva f, Carlos Ramon Silveira Mendes a,g,∗
a Hospital Santa Izabel – Santa Casa da Bahia, Servic¸ o de Coloproctologia, Salvador, BA, Brazil b Núcleo de Oncologia da Bahia, Salvador, BA, Brazil
c Hospital Santa Izabel – Santa Casa da Bahia, Servic¸ o de Radioterapia, Salvador, BA, Brazil d Hospital Santa Izabel – Santa Casa da Bahia, Servic¸ o de Oncologia Clínica, Salvador, BA, Brazil e Clinica AMO, Salvador, BA, Brazil f Obras Sociais de Irmã Dulce (OSID), Salvador, BA, Brazil g Universidade de São Paulo (USP), Salvador, BA, Brazil
Quality of life
∗ Corresponding author.
Objective: To describe the partial results of a study in patients with rectal cancer who under-went neoadjuvant treatment with chemotherapy and radiotherapy regarding the rate of complete clinical response, disease-free survival, anorectal function, and quality of life.
Material and methods: This was a prospective study from June 2015 to June 2018, in patients with low- or mid-rectum adenocarcinoma and clinical stage II or III, treated with radiother-apy and chemotherapy (IMRT 54 Gy for six weeks) concomitant with 5-fluorouracil (5-FU) 380 mg/m2 and folinic acid (LV) 20 mg/m2 for five days in the first and fifth weeks and two cycles after radiotherapy (5-FU 400 mg/m2 and LV 20 mg/m2 ) every 28 days. After the treat-ment, clinical examination, rectosigmoidoscopy, pelvic magnetic resonance imaging, chest and upper abdomen computed tomography, and CEA testing were performed. Resection surgery was performed in those with incomplete clinical response (iCR). Those with com-plete clinical response (cCR) are under observation (wait-and-see policy). Manometry and scintigraphic function and quality of life scales were collected before treatment and at 30 and 90 days after the end of treatment.