br Results br Table compares
Table 1 compares demographic and clinical characteristics between the two groups of patients with BFI-T < 4 or ≥ 4. The mean age of the 170 patients was 58 years and 58% of them were females. Slightly over a half of the patients (51%) received inpatient chemotherapy treatment, and 66% were at cancer stage III–IV. The most common types of cancer,
Demographic and clinical characteristics of the study participants (N = 170).
All patients Patients with Patients with
BFI-T score BFI-T score ≥
BFI-T: Taiwanese version of the Brief Fatigue Inventory.
Comparisons of nine types of traditional Chinese medicine body constitution between patients with mild and moderate-to-severe cancer-related fatigue.
BFI-T: Taiwanese version of the Brief Fatigue Inventory; TCMBC: traditional Chinese medicine body constitution.
P-values obtained from Chi-square or Fisher’s exact test, as appropriate.
Table 2 shows the results comparing the proportions of patients with or without moderate-to-severe fatigue for each of the nine types of TCMBC. The proportion of patients with Gentleness TCMBC was sig-nificantly higher in those Ruxolitinib without moderate-to-severe cancer-related fatigue (P < 0.001). Conversely, the proportions of patients with Qi-deficiency (P < 0.001), Yang-deficiency (P < 0.001), and Qi-depres-sion (P = 0.005) TCMBC were significantly higher in those with mod-erate-to-severe cancer-related fatigue. No significant diﬀerences were observed between the two groups in the remaining four types of TCMBC.
Of the 170 patients, 78 were classified as having only one type of TCMBC, whereas 87 and 5 were classified as having two or three types of TCMBC, respectively. Moreover, of those with two types of TCMBC, the most common combination was Qi-deficiency and Yang-deficiency (15, 8.8%), followed by Qi-deficiency and Qi-depression (8 patients, 4.7%) and Yang-deficiency and Qi-depression (6 patients, 3.5%).
Other independent variables included during the evaluation of the multiple logistic regression model included age, sex, body mass index, systolic blood pressure, diastolic blood pressure, cancer treatment, cancer stage, Qi-depression TCMBC, Yin-deficiency TCMBC, Phlegm-
Multiple logistic regression analysis of moderate-to-severe cancer-related fa-tigue.
Variable Odds ratio (95% confidence interval) P value
wetness TCMBC, Blood-stasis TCMBC, Wetness-heat TCMBC, and Special diathesis TCMBC.
This study is the first to show a significant association between TCMBC and moderate-to-severe cancer-related fatigue in cancer pa-tients. Specifically, patients with Qi-deficiency TCMBC and Yang-defi-ciency TCMBC were independently associated with a higher risk of moderate-to-severe cancer-related fatigue, whereas those with a Gentleness TCMBC were independently associated with a lower risk of moderate-to-severe cancer-related fatigue. The larger magnitude in the adjusted odds ratio for Yang-deficiency (aOR = 3.55) compared with that for Qi-deficiency (aOR = 2.84) was consistent with the TCM theory that Yang-deficiency generally represents a more severe condition than Qi-deficiency. Conversely, the significant inverse association between a Gentleness TCMBC was also in line with the TCM theory. Individuals with a Gentleness TCMBC mean that their bodily condition is in a state of relative balance of Yin and Yang. These individuals are therefore, less prone to suﬀer from moderate-to-severe cancer-related fatigue.