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Biomarker Panel for Early Detection of Endometrial Cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
Christopher M. Tarney, MD, Guisong Wang, MS, Nicholas W. Bateman, PhD, Kelly A. Conrads, PhD, Ming Zhou, PhD, Brian L. Hood, PhD, Jeremy Loffredo, BS, Chunqiao Tian, PhD, Kathleen M. Darcy, PhD, Chad A. Hamilton, MD, Yovanni Casablanca, MD, Anna Lokshin, PhD, Thomas P. Conrads, G. Larry Maxwell, MD
To appear in: American Journal of Obstetrics and Gynecology
Please cite this article as: Tarney CM, Wang G, Bateman NW, Conrads KA, Zhou M, Hood BL, Loffredo J, Tian C, Darcy KM, Hamilton CA, Casablanca Y, Lokshin A, Conrads TP, Maxwell GL, Biomarker Panel for Early Detection of Endometrial Cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, American Journal of Obstetrics and Gynecology (2019), doi: https://doi.org/10.1016/ j.ajog.2019.06.005.
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ACCEPTED MANUSCRIPT
1 TITLE: Biomarker Panel for Early Detection of Endometrial Cancer in the Prostate, Lung,
2 Colorectal, and Ovarian Cancer Screening Trial
4 AUTHORS: Christopher M. TARNEY MDa, Guisong WANG MSa, Nicholas W. BATEMAN
5 PhDa,b, Kelly A. CONRADS PhDa, Ming ZHOU PhDa, Brian L. HOOD PhDa, Jeremy
6 LOFFREDO BSa, Chunqiao TIAN PhDa,b, Kathleen M. DARCY PhDa,b, Chad A. HAMILTON
7 MDa,d, Yovanni CASABLANCA MDa,b, Anna LOKSHIN PhDe, Thomas P. CONRADSa-d and
8 G. Larry MAXWELL MDa-d
9 a Gynecologic Cancer Center of Excellence, Department of Obstetrics & Gynecology, Walter
10 Reed National Military Medical Center, Uniformed Services University of the Health
11 Sciences, Bethesda MD, United States
12 b John P Murtha Cancer Center, Walter Reed National Military Medical Center, Uniformed 13
Services University of the Health Sciences, Bethesda MD, United States 14 c Inova Schar Cancer Institute, Inova Center for Personalized Health, Falls Church, VA, United 15
States 16 d Department of Obstetrics and Gynecology, Inova Fairfax Hospital, Falls Church, VA, United 17
States 18 e University of Pittsburgh Medical Center, Pittsburgh, PA, United States 19
20 Declaration of Interests: The authors report no conflict of interest.
23 University of the Health Sciences from the Defense Health Program.
ACCEPTED MANUSCRIPT
24 Presentations: Presented at the American College of Obstetricians and Gynecologists Armed
25 Forces District Meeting, September 23-26, 2018, Honolulu HI and at the Society of Gynecologic
26 Oncology Annual Meeting on Women’s Cancer, March 16-19, Honolulu HI
28 Disclaimer: The views expressed herein are those of the authors and do not reflect the official
29 policy of the Department of Army/Navy/Air Force, Department of Defense, or U.S. Government.
31 Corresponding Author: G. Larry Maxwell MD, Department of Obstetrics and Gynecology,
33 [email protected], or Thomas P. Conrads, PhD, Inova Schar Cancer Institute, 3289
ACCEPTED MANUSCRIPT
46 Condensation: A biomarker panel consisting of six proteins distinguished endometrial cancer
47 cases from controls ≤ 2 years from diagnosis using prediagnostic serum.
49 Short Title: Biomarker Panel for Early Detection of Endometrial Cancer